Highly highly depends on the type of music, the way it was recorded, the age of the music, etc.
I was gifted Alison wonderland on vinyl, it honestly sounds exactly the same as digital.
But all my favourite rock bands, the digital feels not only a bit lifeless but artificially enhanced.
Ergonomically you want a TKL, then mouse, then numpad, or numpad, then TKL, then mouse.
A full size keyboard pushes your mouse out so far you can never have your most common keys and input device both in a good ergonomic range.