I’ve had my ESS AMT6 professionals for 2.5 years now, they’re the size of small refrigerators so I mistakenly believed that toeing them in towards my listening position wouldn’t do much due to the size of my living room and shape of my house. They truly fill my house with beautiful music from anywhere I am (depending how loud I turn them up) Anyways about a week ago I toed them in to my main listening position and lo and behold the right channel opened right up and the soundstage is much more balanced, with depth and just a huge improvement overall. I’m simultaneously delighted and annoyed I didn’t do this years ago! So please, do yourself a favor if you have gigantic speakers and haven’t done so yet, toe them in and reap the rewards.
It costs nothing to try. That’s the key bit.
There’s no single answer, but almost every speaker will benefit from the reduced side wall interactions since the walls become even more off-axis with regard to the tweeters. And heck, constant directivity speakers often sound better with even more toe, to the point where they’re crossed some 16" or more in front of the listener.
Toe in is as much about the interaction between the speaker and the room as it is between you and the speaker.